Cyclic adenosine monophosphate (cAMP) and cAMP‐dependent protein kinase A (PKA) are evolutionary conserved molecules with a well‐established position in the complex network of signal transduction pathways. cAMP/PKA‐mediated signaling pathways are implicated in many biological processes that cooperate in organ development including the motility, survival, proliferation and differentiation of epithelial cells. Cell surface polarity, here defined as the anisotropic organisation of cellular membranes, is a critical parameter for most of these processes. Changes in the activity of cAMP/PKA elicit a variety of (...) effects on intracellular membrane dynamics, including membrane sorting and trafficking. One of the most intriguing aspects of cAMP/PKA signaling is its evolutionary conserved abundance on the one hand and its precise spatial–temporal actions on the other. Here, we review recent developments with regard to the role of cAMP/PKA in the regulation of intracellular membrane trafficking in relation to the dynamics of epithelial surface domains. BioEssays 30:146–155, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Tacitus writes that, by insisting that legionary legates who had not so far held the praetorship should immediately proceed to that office, Asinius Gallus ‘altius penetrare et arcana imperii temptari’. In C.Q. N.S. xvi , 327, I suggested that this demand of Gallus’ was probably probing dangerously deeply into and perhaps threatening to wreck the carefully worked-out imperial promotions system, the working of which has been examined by Birley. It is the purpose of this note to look at a number (...) of examples of such irregularity, which, though not as early as the debate during the course of which Gallus made his suggestion, do at least illustrate the process later in the Julio-Claudian era. (shrink)

In his historical writings, Cluvius Rufus evidently found cause to criticize Verginius Rufus for his conduct on a particular occasion ‘Scis, Vergini, quae historiae fides debeatur; proinde, si quid in historiis meis legis aliter ac velles, rogo igmoscas’. From his reply, it is clear that Verginius automatically understood Cluvius to be referring to an event to which he himself attached great significance: ‘Tune ignoras, Cluvi, ideo me fecisse, quod feci, ut esset liberum vobis scribere quae libuisset?’.

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

Although Broad published many books in his lifetime, this volume is unique in presenting some of his most interesting unpublished writings. Divided into five clear sections, the following figures and topics are covered: Autobiography, Hegel and the nature of philosophy, Francis Bacon, Hume's philosophy of the self and belief, F. H. Bradley, The historical development of scientific thought from Pythagoras to Newton, Causation, Change and continuity, Quantitative methods, Poltergeists, Paranormal phenomena. -/- Each section is introduced and placed in context by (...) the editor, Joel Walmsley. The volume also includes an engaging and informative foreword by Simon Blackburn. It will be of great value to those studying and researching the history of twentieth-century philosophy, metaphysics, and the recent history and philosophy of science, as well as anyone interested in Broad's philosophical thought and his place in the history of philosophy. (shrink)

Eliminative reasoning is a method that has been employed in many significant episodes in the history of science. It has also been advocated by some philosophers as an important means for justifying well-established scientific theories. Arguments for how eliminative reasoning is able to do so, however, have generally relied on a too narrow conception of evidence, and have therefore tended to lapse into merely heuristic or pragmatic justifications for their conclusions. This paper shows how a broader conception of evidence not (...) only can supply the needed justification but also illuminates the methodological significance of eliminative reasoning in a variety of contexts. (shrink)

In this groundbreaking work, C. D. C. Reeve uses a fundamental problem--the Primacy Dilemma--to explore Aristotle's metaphysics, epistemology, dialectic, philosophy of mind, and theology in a new way. At a time when Aristotle is most often studied piecemeal, Reeve attempts to see him both in detail and as a whole, so that it is from detailed analysis of hundreds of particular passages, drawn from dozens of Aristotelian treatises, and translated in full that his overall picture of Aristotle emerges. Primarily a (...) book for philosophers and advanced students with an interest in the fundamental problems with which Aristotle is grappling, Substantial Knowledge's clear, non-technical and engaging style will appeal to any reader eager to explore Aristotle's difficult but extraordinarily rewarding thought. (shrink)

Reeve's classic work provides an interpretation of Republic that makes a case for the coherence of Plato's argument.

In this paper I propose an interpretation of classical statistical mechanics that centers on taking seriously the idea that probability measures represent complete states of statistical mechanical systems. I show how this leads naturally to the idea that the stochasticity of statistical mechanics is associated directly with the observables of the theory rather than with the microstates (as traditional accounts would have it). The usual assumption that microstates are representationally significant in the theory is therefore dispensable, a consequence which suggests (...) interesting possibilities for developing non-equilibrium statistical mechanics and investigating inter-theoretic answers to the foundational questions of statistical mechanics. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

Readers familiar with the workhorse of cosmology, the hot big bang model, may think that cosmology raises little of interest about time. As cosmological models are just relativistic spacetimes, time is understood just as it is in relativity theory, and all cosmology adds is a few bells and whistles such as inflation and the big bang and no more. The aim of this chapter is to show that this opinion is not completely right...and may well be dead wrong. In our (...) survey, we show how the hot big bang model invites deep questions about the nature of time, how inflationary cosmology has led to interesting new perspectives on time, and how cosmological speculation continues to entertain dramatically different models of time altogether. Together these issues indicate that the philosopher interested in the nature of time would do well to know a little about modern cosmology. (shrink)

A critical and detailed introduction to Kant's philosophy, with particular reference to the Critique of Pure Reason. Since Broad's death there have been many publications on Kant but Broad's 1978 book still finds a definite place between the very general surveys and the more specialised commentaries. He offers a characteristically clear, judicious and direct account of Kant's work; his criticisms are acute and sympathetic, reminding us forcefully that 'Kant's mistakes are usually more important than other people's correctitudes'. C.D. Broad was (...) Knightsbridge Professor of Moral Philosophy at Cambridge from 1933 to 1953, and this book is based on his undergraduate lectures on Kant. Broad died in 1971 and Dr Lewy has since edited the book for publication. (shrink)

C. D. C. Reeve develops a powerful new account of the age-old argument over whether the just are happier than the unjust, drawing from a new understanding of Plato's conception of philosophy.

This book is an exploration of the epistemological, metaphysical, and psychological foundations of the Nicomachean Ethics. In a striking reversal of current orthodoxy, Reeve argues that scientific knowledge (episteme) is possible in ethics, that dialectic and understanding (nous) play essentially the same role in ethics as in an Aristotelian science, and that the distinctive role of practical wisdom (phronesis) is to use the knowledge of universals provided by science, dialectic, and understanding so as to best promote happiness (eudaimonia) in particular (...) circumstances and to ensure a happy life. Turning to happiness itself, Reeves develops a new account of Aristotle's views on ends and functions, exposing their twofold nature. He argues that the activation of theoretical wisdom is primary happiness, and that the activation of practical wisdom--when it is for the sake of primary happiness--is happiness of a secondary kind. He concludes with an account of the virtues of character, external goods, and friends, and their place in the happy life. (shrink)

"Reeve's book is an excellent companion to Plato's Apology and a valuable discussion of many of the main issues that arise in the early dialogues. Reeve is an extremely careful reader of texts, and his familiarity with the legal and cultural background of Socrates' trial allows him to correct many common misunderstandings of that event. In addition, he integrates his reading of the apology with a sophisticated discussion of Socrates' philosophy. The writing is clear and succinct, and the research is (...) informed by a thorough acquaintance with the secondary literature. Reeve's book will be accessible to any serious undergraduate, but it is also a work that will have to be taken into account by every scholar doing advanced research on Socrates." --Richard Kraut, Northwestern University. (shrink)

O artigo oferece uma breve exposição da biografia e do contexto histórico do filósofo neoplatônico Damáscio (c. 458 - c. 538) para, na sequência, apresentar a tradução de um dos seus poemas líricos do período final de sua vida. O procedimento adotado justifica-se pelo caráter lutuoso e decididamente pessoal dos versos, nos quais Damáscio lamenta consigo próprio as perdas sofridas no decorrer de sua longa e fascinante vida. Como veremos, tais perdas estão, em verdade, diretamente ligadas ao colapso do mundo (...) antigo e ao derradeiro golpe proferido por Justiniano contra a filosofia helênica pagã. (shrink)

In Aristotle's views on cognition a series of terms – hupolêpsis, doxa, and epistêmê – play key roles. But it has not been noticed that each of these comes in two kinds – one unqualified and the other qualified. When these and their interrelations are properly explored, a deeply systematic picture of cognition emerges, in which doxa is best understood as ‘belief’, hupolêpsis as ‘supposition’, and epistêmê as a sort of belief, so that – contrary to orthodoxy – we can (...) have belief and knowledge of the same things at the same time. Many of these conclusions are shown to mark a continuity with Plato, in that neither thinker, it is argued, holds a so-called ‘two-worlds’ picture of cognition. (shrink)

I discuss the formal implementation, interpretation, and justification of likelihood attributions in cosmology. I show that likelihood arguments in cosmology suffer from significant conceptual and formal problems that undermine their applicability in this context.

_Rhetoric_ is the sixth volume in The New Hackett Aristotle series, a series featuring translations, with Introductions and Notes, by C. D. C. Reeve, Delta Kappa Epsilon Distinguished Professor of Philosophy at The University of North Carolina at Chapel Hill. The series will eventually include all of Aristotle's works.

I will begin this paper by stating in rough outline what I consider to be the relevance of psychical research to philosophy, and I shall devote the rest of it to developing this preliminary statement in detail.

We introduce a novel point of view on the “models as mediators” framework in order to emphasize certain important epistemological questions about models in science which have so far been little investigated. To illustrate how this perspective can help answer these kinds of questions, we explore the use of simplified models in high energy physics research beyond the Standard Model. We show in detail how the construction of simplified models is grounded in the need to mitigate pressing epistemic problems concerning (...) the uncertainty inherent in the present theoretical and experimental contexts. (shrink)

The transmission of form and soul -- Desire, perception, and understanding -- Theoretical wisdom -- Virtue of character -- Practical wisdom -- Immortalizing beings -- Happiness -- The happiest life.

Cosmological inflation is widely considered an integral and empirically successful component of contemporary cosmology. It was originally motivated by its solution of certain so-called fine-tuning problems of the hot big bang model, particularly what are known as the horizon problem and the flatness problem. Although the physics behind these problems is clear enough, the nature of the problems depends on the sense in which the hot big bang model is fine-tuned and how the alleged fine-tuning is problematic. Without clear explications (...) of these, it remains unclear precisely what problems inflationary theory is meant to be solving and whether it does in fact solve them. I analyze the structure of these problems and consider various interpretations that may substantiate the alleged fine-tuning. On the basis of this analysis I argue that at present there is no unproblematic interpretation available for which it can be said that inflation solves the big bang model’s alleged fine-tuning problems. (shrink)

This book shows you what it is like to think along with Aristotle and helps you to see the universe and our place in it as he thought they had to be seen to be scientifically intelligible. As a portrait is composed of colors and shapes that collectively represent someone, so Aristotles works are composed of arguments that collectively represent the causal structure of the universe, from the stones, plants, and animals around us to the starry heavens above and the (...) god beyond them. The aim of this brief immersion is to guide you through those arguments in a way that lets you understand for yourself why they proceed as they do and end where they do."--Publisher. (shrink)

The conspicuous similarities between interpretive strategies in classical statistical mechanics and in quantum mechanics may be grounded on their employment of common implementations of probability. The objective probabilities which represent the underlying stochasticity of these theories can be naturally associated with three of their common formal features: initial conditions, dynamics, and observables. Various well-known interpretations of the two theories line up with particular choices among these three ways of implementing probability. This perspective has significant application to debates on primitive ontology (...) and to the quantum measurement problem. (shrink)

This volume contains C. D. Broad's Cambridge lectures on Ethics. Broad gave a course of lectures on the subject, intended primarily for Part I of the Moral Sciences Tripos, every academic year from 1933 - 34 up to and in cluding 1952 - 53 (except that he did not lecture on Ethics in 1935 - 36). The course however was frequently revised, and the present version is es sentially that which he gave in 1952 - 53. Broad always wrote out (...) his lectures fully beforehand, and the manuscript on Ethics, although full of revisions, is in a reasonably good state. But his handwriting is small and close and in places difficult to decipher. I therefore fear that some words may have been misread. There was an additional complication. In the summer of 1953 Broad revised and enlarged two sections of the course, namely the section on "Moore's theory" and that on "Naturalistic theories" (both sections occur in Chapter 4). The revised version of the section on Moore is undoubtedly superior to the earlier version, and I have therefore included it. But in my opinion this is not true of the new version of the section on naturalistic theories: although more comprehensive than the earlier version, it is not only repetitive in itself, but also repeats, sometimes almost verbatim, passages which occur elsewhere in the lectures. In brief, the new version is not fully integrated with the rest of the course. (shrink)

I present a recent historical case from cosmology—the story of inflationary cosmology—and on its basis argue that solving explanatory problems is a reliable method for making progress in science. In particular, I claim that the success of inflationary theory at solving its predecessor’s explanatory problems justified the theory epistemically, even in advance of the development of novel predictions from the theory and the later confirmation of those predictions.

I want to state the theory in An Experiment with Time as clearly as I can in my own way; then to consider its application to Precognition; and then to consider whether there are any other grounds for accepting it beside its capacity to account for the possibility of Precognition. Mr. Dunne himself holds that the theory is required quite independently of explaining Precognition. He also holds that the facts which demand a serial theory of Time require that the series (...) shall be infinite. Both these contentions might be mistaken, and yet Mr. Dunne might be right to the extent that it is necessary to assume a series of at least two terms for the special purpose of explaining Precognition. (shrink)

Sense-perception is a hackneyed topic, and I must therefore begin by craving your indulgence. I was moved to make it the subject of this evening's lecture by the fact that I have lately been reading the book in which the most important of the late Professor Prichard's scattered writings on Sense-perception have been collected by Sir W. D. Ross. Like everything that Prichard wrote, these essays are extremely acute, transparently honest, and admirably thorough. I shall not attempt here either to (...) expound or to criticize Prichard, but he may be taken to be hovering, perhaps somewhat disapprovingly, in the background during the lecture. (shrink)

"It is... remarkable that Reeve's is the first new English translation since Fowler's Loeb edition of 1926. Fortunately, Reeve has done an excellent job. His version is not slavishly literal but is in general very accurate. It is also very clear and readable. Reeve is particularly to be congratulated for having produced versions of some of the more torturous passages, which are not only faithful to the text but also make good sense in English. The long and detailed introduction is (...) worth reading in its own right." --R. F. Stalley, _The Classical Review_. (shrink)